Apoptotic processes during mammalian preimplantation development

Theriogenology. 2005 Jul 15;64(2):221-31. doi: 10.1016/j.theriogenology.2004.11.022. Epub 2005 Jan 1.


The paper provides a review of the current state of knowledge on apoptosis during normal preimplantation development based on the literature and on the authors' own findings. Information is focused on the occurrence and the characteristics of spontaneous apoptotic processes. Reports concerning the chronology and the incidence of programmed cell death in mouse, cow, pig and human embryos in early preimplantation stages up to the blastocyst stage are summarized. In addition, specific attributes of the apoptotic process in mammalian preimplantation development are provided, including the description of both morphological and biochemical features of cell death.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Blastocyst
  • Cleavage Stage, Ovum
  • DNA Fragmentation
  • Embryonic Development / physiology*
  • In Situ Nick-End Labeling