Effect of dietary supplementation with glucomannan on plasma total cholesterol and low density lipoprotein cholesterol in hypercholesterolemic children

Nutr Metab Cardiovasc Dis. 2005 Jun;15(3):174-80. doi: 10.1016/j.numecd.2004.04.004.


Aim: This paper evaluates the effect of the adjunct of the hydrosoluble fiber glucomannan to a Step-One-Diet in 40 plasma hypercholesterolemic children, during a randomized controlled trial, to reduce plasma cholesterol.

Methods: All the subjects recruited underwent an 8-week run in diet period; a Step-One-Diet was prescribed. After that, they were randomly allocated to one of two groups: Step-One-Diet only (control), and Step-One-Diet plus glucomannan in gelatine capsules. After another 8 weeks of treatment, the results were compared within and between the two groups.

Results: Glucomannan treated group showed decreased values in plasma total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) vs. control group after 8 weeks of treatment. The percentage decrease showed a statistically significant difference between sex groups. Decreases were observed in favor of female vs. male children in TC (24% vs. 9%) and LDL-C (30% vs. 9%).

Conclusions: These results suggest that glucomannan may represent a rationale adjunct to diet therapy in primary prevention in high risk hypercholesterolemic children.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Anticholesteremic Agents / administration & dosage
  • Anticholesteremic Agents / pharmacology*
  • Child
  • Cholesterol / blood*
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood*
  • Combined Modality Therapy
  • Diet, Fat-Restricted
  • Dietary Supplements
  • Female
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / diet therapy
  • Hypercholesterolemia / drug therapy*
  • Male
  • Mannans / administration & dosage
  • Mannans / pharmacology*
  • Sex Factors
  • Treatment Outcome
  • Triglycerides / blood


  • Anticholesteremic Agents
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Mannans
  • Triglycerides
  • (1-6)-alpha-glucomannan
  • Cholesterol