FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded

Bioinformatics. 2005 Aug 15;21(16):3435-8. doi: 10.1093/bioinformatics/bti537. Epub 2005 Jun 14.


An easy-to-use, versatile and freely available graphic web server, FoldIndex is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Computer Graphics
  • Computer Simulation
  • Energy Transfer
  • Internet
  • Models, Chemical*
  • Models, Molecular*
  • Protein Conformation
  • Protein Folding
  • Proteins / analysis
  • Proteins / chemistry*
  • Sequence Alignment / methods*
  • Sequence Analysis, Protein / methods*
  • Software*
  • Structure-Activity Relationship
  • User-Computer Interface*


  • Proteins