Automated measurement of intima-media thickness of carotid arteries in ultrasonography by computer software

Diagn Interv Radiol. 2005 Jun;11(2):105-8.


Purpose: Intima-media thickness (IMT) has been proposed to be a morphological criterion of atherosclerosis. The purpose of this study was to investigate the interobserver variability of manual and also of computer software measurements of IMT.

Materials and methods: High-resolution common carotid artery (CCA) images of 88 patients that have been obtained by a linear broadband L5-12 MHz transducer and archived in PACS were retrospectively evaluated. Two separate investigators, who were unaware of the former results, evaluated the same images by using computer software that had a dedicated tool for automatic measurement of IMT. The results of the investigators were compared.

Results: According to the two investigators who have performed manual measurements, mean values of IMT of right CCA were 0.6396 mm and 0.6356 mm; of the left CCA were 0.6662 mm and 0.6575 mm, respectively. The interobserver variability of measurements revealed the mean IMT as 0.6071 mm and 0.6048 mm for the right, 0.6216 mm and 0.6227 mm for the left CCA. Manual measurements of both investigators were found to be higher than the automatic measurements and the differences were statistically significant. Interobserver correlation of manual measurements was between 0.80-0.88 and of the automated measurements was between 0.93-0.98.

Conclusion: Manual measurements reveal higher values than the automated measurements of IMT. The interobserver correlation of automated measurements is higher than manual measurements. The use of dedicated software may be proposed to reduce the measurement errors.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Arteriosclerosis / diagnostic imaging*
  • Automation
  • Carotid Artery, Common / diagnostic imaging*
  • Female
  • Humans
  • Image Processing, Computer-Assisted*
  • Male
  • Observer Variation
  • Predictive Value of Tests
  • Software
  • Tunica Intima / diagnostic imaging
  • Ultrasonography