Cu(OAc)2-catalyzed N-arylations of sulfoximines with aryl boronic acids

Christian Moessner; Carsten Bolm

doi:10.1021/ol050816a

Cu(OAc)2-catalyzed N-arylations of sulfoximines with aryl boronic acids

Org Lett. 2005 Jun 23;7(13):2667-9. doi: 10.1021/ol050816a.

Authors

Christian Moessner¹, Carsten Bolm

Affiliation

¹ Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany.

PMID: 15957917
DOI: 10.1021/ol050816a

Abstract

[reaction: see text] A simple and mild copper salt-catalyzed N-arylation of sulfoximines in high yields is reported. Cu(OAc)(2) activates aryl boronic acids for the reaction with NH-sulfoximines without additional base or heating. Furthermore, this new method allows the preparation of N-arylated sulfoximines, which have previously been more difficult to access.