Clinical risk factors associated with bleeding after native kidney biopsy

Nephrology (Carlton). 2005 Jun;10(3):305-10. doi: 10.1111/j.1440-1797.2005.00394.x.


Purpose: To determine the effect of various risk factors on postbiopsy bleeding (PBB).

Procedure: A retrospective review of 645 native kidney biopsies carried out from 1981 to 2001 was conducted. Data regarding age, gender, race, prebiopsy blood pressure, history of hypertension, pre- and postbiopsy haemoglobin/haematocrit, serum creatinine and blood urea nitrogen (BUN) were collected.

Findings: The overall PBB complication rate was 6.2%. High blood pressure was associated with a high risk of bleeding (test for trend, P < 0.05). It increased when systolic blood pressure (SBP) was >160 mm of Hg, diastolic blood pressure (DBP) was >100 mm of Hg, or mean arterial pressure (MAP) was > or = 120 mm of Hg. In patients with a history of hypertension, the risk of PBB was 3.74 times higher (P = 0.0001) than patients with no history of hypertension, irrespective of blood pressure at the time of biopsy. For patients with creatinine > 2 mg/dL, the risk ratio for PBB was 5.89 when compared with patients with creatinine < or = 2 mg/dL. Logistic regression analysis showed that a history of hypertension was associated with PBB, with an odds ratio of 1.89 (confidence interval, 1.10-3.26, P < 0.03), and serum creatinine of > 2.0 mg/dL was associated with an odds ratio of 2.56 (confidence interval, 1.48-4.42, P = 0.001) for PBB.

Conclusions: The risk of PBB increases with high SBP, DBP or MAP. A history of hypertension and high serum creatinine are significant independent risk factors for PBB.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Biopsy / adverse effects*
  • Biopsy / statistics & numerical data*
  • Blood Pressure
  • Creatinine / blood
  • Female
  • Hemorrhage / epidemiology*
  • Hemorrhage / etiology
  • Humans
  • Hypertension, Renal / epidemiology
  • Hypertension, Renal / pathology
  • Kidney Diseases / epidemiology*
  • Kidney Diseases / pathology*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors


  • Creatinine