Chemokines in tumor progression and metastasis

Cancer Sci. 2005 Jun;96(6):317-22. doi: 10.1111/j.1349-7006.2005.00059.x.


Although chemokines have been thought of primarily as leukocyte attractants, a growing body of evidence indicates that they also contribute to a number of tumor-related processes, such as tumor cell growth, angiogenesis/angiostasis, local invasion, and metastasis. The current knowledge of the possible involvement of chemokines and their receptors in these cellular events are reviewed here. The operating mechanism of chemokines in relation to metastatic processes in vivo are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Survival
  • Chemokines / physiology*
  • Disease Progression
  • Humans
  • Neoplasm Metastasis / immunology*
  • Neoplasms / immunology*
  • Neoplasms / physiopathology*
  • Neovascularization, Pathologic
  • Receptors, Chemokine / physiology*


  • Chemokines
  • Receptors, Chemokine