The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence

Int J Colorectal Dis. 2006 Apr;21(3):201-8. doi: 10.1007/s00384-005-0776-8. Epub 2005 Jun 16.


Objective: The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy.

Materials and methods: Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer.

Results: The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources.

Conclusion: Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / blood
  • Cell Line, Tumor
  • Colorectal Neoplasms / blood
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / physiopathology*
  • Humans
  • Insulin-Like Growth Factor I / physiology
  • Insulin-Like Growth Factor II / physiology
  • Risk Factors
  • Somatomedins / physiology*


  • Biomarkers, Tumor
  • Somatomedins
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II