Enhanced peptide beta-sheet affinity by metal to ligand coordination

J Org Chem. 2005 Jun 24;70(13):5305-8. doi: 10.1021/jo0502908.

Abstract

A histidine-coordinating metal complex substituted with methoxypyrrole amino acids (MOPAS) as a peptide beta-sheet binder shows high affinity for a H(2)N-His-Leu-Leu-Val-Phe-OMe pentapeptide in DMSO solution. Within the complex, a beta-sheet conformation is induced into the pentapeptide by weak intra-assembly interactions with the MOPAS units.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / chemistry*
  • Ligands
  • Models, Molecular*
  • Molecular Structure
  • Oligopeptides / chemistry*
  • Protein Conformation
  • Protein Structure, Secondary*
  • Stereoisomerism

Substances

  • Amino Acids
  • H(2)N-His-Leu-Leu-Val-Phe-OMe
  • Ligands
  • Oligopeptides