Histone modifications: from genome-wide maps to functional insights

Genome Biol. 2005;6(6):113. doi: 10.1186/gb-2005-6-6-113. Epub 2005 May 31.


A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Animals
  • Gene Expression Regulation
  • Genome / genetics*
  • Histones / metabolism*
  • Humans
  • Models, Biological
  • Nucleosomes / genetics
  • Nucleosomes / metabolism


  • Histones
  • Nucleosomes