Abstract
(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA(2) inhibitory activities with IC(50) values of 45.0 and 52.0 microM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Alkyl-2-acetylglycerophosphocholine Esterase
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Glycerides / isolation & purification*
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Glycerides / pharmacology
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Inhibitory Concentration 50
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Molecular Structure
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Phospholipases A / antagonists & inhibitors
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Phospholipases A / metabolism*
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Phospholipases A2
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Plant Roots / chemistry*
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Plants, Medicinal
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Saururaceae / chemistry*
Substances
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Glycerides
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glyceryl monostearate
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Phospholipases A
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Phospholipases A2
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1-Alkyl-2-acetylglycerophosphocholine Esterase
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monolinolein