Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots

Bioorg Med Chem Lett. 2005 Aug 1;15(15):3573-5. doi: 10.1016/j.bmcl.2005.05.056.

Abstract

(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA(2) inhibitory activities with IC(50) values of 45.0 and 52.0 microM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • Glycerides / isolation & purification*
  • Glycerides / pharmacology
  • Inhibitory Concentration 50
  • Molecular Structure
  • Phospholipases A / antagonists & inhibitors
  • Phospholipases A / metabolism*
  • Phospholipases A2
  • Plant Roots / chemistry*
  • Plants, Medicinal
  • Saururaceae / chemistry*

Substances

  • Glycerides
  • glyceryl monostearate
  • Phospholipases A
  • Phospholipases A2
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • monolinolein