Improved infrared spectrophotometer for point-of-care patient 13C-urea breath testing in the primary care setting

Clin Biochem. 2005 Aug;38(8):731-4. doi: 10.1016/j.clinbiochem.2005.05.003.


The 13C-urea breath test provides non-invasive testing for Helicobacter pylori infection with the possibility of analysis at the point of care. Point of care tests require accurate and efficient desktop instrumentation.

Objective: To compare results obtained from a new infrared spectrophotometer (10 kg, 2 min sample measurement) to the previously approved UBiT-IR300 (22.5 kg, 5-6 min sample measurement).

Design and methods: Adults underwent urea breath testing; breath samples were analyzed using the new and the predicate instruments.

Results: There were 220 adults enrolled (age range 18-74 years; M/F = 35:65); with 86 UBT positive and 134 negative cases. The overall agreement between instruments was 99.6% (95% C.I. = 97.6 to 99.9); the positive agreement was 100%.

Conclusion: Technical performance of the new instrument was excellent.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Breath Tests / instrumentation*
  • Breath Tests / methods
  • Carbon Isotopes
  • Female
  • Helicobacter Infections / diagnosis
  • Helicobacter pylori
  • Humans
  • Male
  • Middle Aged
  • Point-of-Care Systems*
  • Primary Health Care
  • Prospective Studies
  • Spectrophotometry, Infrared / instrumentation*
  • Urea*


  • Carbon Isotopes
  • Urea