DNA repair: how to PIKK a partner

Curr Biol. 2005 Jun 21;15(12):R473-5. doi: 10.1016/j.cub.2005.06.012.

Abstract

In eukaryotes, members of the phosphoinositide-3-kinase-related protein kinase (PIKK) family co-ordinate the cellular response to DNA damage. But how do these important kinases detect DNA damage and relay this information to the DNA repair and checkpoint machinery?

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Nuclear / metabolism
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Checkpoint Kinase 2
  • DNA Repair / physiology*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Exodeoxyribonucleases / metabolism
  • Humans
  • Ku Autoantigen
  • MRE11 Homologue Protein
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism*
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Antigens, Nuclear
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • MRE11 protein, human
  • NBN protein, human
  • Nuclear Proteins
  • Phosphoproteins
  • Tumor Suppressor Proteins
  • Protein Kinases
  • Checkpoint Kinase 2
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • CHEK2 protein, human
  • Protein Serine-Threonine Kinases
  • Exodeoxyribonucleases
  • MRE11 Homologue Protein
  • three prime repair exonuclease 1
  • Xrcc6 protein, human
  • Ku Autoantigen