Abstract
In eukaryotes, members of the phosphoinositide-3-kinase-related protein kinase (PIKK) family co-ordinate the cellular response to DNA damage. But how do these important kinases detect DNA damage and relay this information to the DNA repair and checkpoint machinery?
MeSH terms
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Animals
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Antigens, Nuclear / metabolism
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Ataxia Telangiectasia Mutated Proteins
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism*
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Checkpoint Kinase 2
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DNA Repair / physiology*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Exodeoxyribonucleases / metabolism
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Humans
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Ku Autoantigen
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MRE11 Homologue Protein
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism*
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Phosphatidylinositol 3-Kinases / metabolism*
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Phosphoproteins / metabolism
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Phosphorylation
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Protein Kinases / metabolism*
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism*
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / metabolism*
Substances
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Antigens, Nuclear
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Cell Cycle Proteins
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DNA-Binding Proteins
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MRE11 protein, human
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NBN protein, human
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Nuclear Proteins
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Phosphoproteins
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Tumor Suppressor Proteins
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Protein Kinases
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Checkpoint Kinase 2
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ATM protein, human
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Ataxia Telangiectasia Mutated Proteins
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CHEK2 protein, human
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Protein Serine-Threonine Kinases
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Exodeoxyribonucleases
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MRE11 Homologue Protein
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three prime repair exonuclease 1
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Xrcc6 protein, human
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Ku Autoantigen