Histological and histochemical assessment of the effects of a single dose adriamycin on fetal rat kidney

Acta Histochem. 2005;107(3):215-20. doi: 10.1016/j.acthis.2005.02.004.

Abstract

Adriamycin (ADR) induces nephritic syndrome (NS) in adult rats. Therefore, effects of ADR in a single dose of 5mg/kg body weight given intraperitoneally to the mothers at 4 weeks before pregnancy were assessed on fetal rat kidneys in the present study. It induces increased amounts of PAS(+)-positive mesangial matrix, glomerulosclerosis, dilatation of the urinary space and thickening of basement membranes in glomeruli. In tubules, it damages or completely destroys epithelial cells, it induces dilatation of the tubular lumen and disintegration of the brush border. Changes in fetal rat kidney as observed light microscopically appeared to be similar to those described in kidneys of adult rats with NS induced by adriamycin, but were less distinct.

MeSH terms

  • Abnormalities, Drug-Induced*
  • Animals
  • Antibiotics, Antineoplastic / toxicity*
  • Doxorubicin / toxicity*
  • Female
  • Fetal Death / chemically induced
  • Fetal Death / pathology
  • Fetal Development / drug effects*
  • Fetal Weight / drug effects
  • Injections, Intraperitoneal
  • Kidney / drug effects*
  • Kidney / embryology
  • Kidney / pathology
  • Maternal Exposure
  • Periodic Acid-Schiff Reaction
  • Rats
  • Rats, Wistar

Substances

  • Antibiotics, Antineoplastic
  • Doxorubicin