Review
doi: 10.1080/08916930400022681.
Anti-Mi-2 antibodies
Affiliations
- PMID: 15966133
- DOI: 10.1080/08916930400022681
Item in Clipboard
Review
Anti-Mi-2 antibodies
Autoimmunity.
2005 Feb.
Free article
Abstract
Autoantibodies targeting the Mi-2 nuclear antigen represent one of the serologic hallmarks of idiopathic inflammatory myopathies, with a diagnostic sensitivity and specificity of approximately 4-18% and 98-100%, respectively. Mi-2 antigen is a component of the nuclesome remodeling-deacetylase (NuRD) complex involved in transcription regulation.Anti-Mi-2 antibodies are strongly associated with dermatomyositis (frequency up to 31%) and have a very high positive predictive value for such disease subset. A strong correlation with HLA-DR7 has been demonstrated. At the moment, optimal serologic testing is achieved by ELISA screening on recombinant Mi-2 antigen and confirmation of positive results on immunoblot.
Similar articles
-
Anti-Jo-1 antibodies.Autoimmunity. 2005 Feb;38(1):73-8. doi: 10.1080/08916930400022640. Autoimmunity. 2005. PMID: 15804708
-
Autoantibodies to Mi-2 alpha and Mi-2 beta in patients with idiopathic inflammatory myopathy.Rheumatology (Oxford). 2019 Sep 1;58(9):1655-1661. doi: 10.1093/rheumatology/kez092. Rheumatology (Oxford). 2019. PMID: 30938432 Review.
-
Anti-SAE antibodies in autoimmune myositis: identification by unlabelled protein immunoprecipitation in an Italian patient cohort.J Immunol Methods. 2012 Oct 31;384(1-2):128-34. doi: 10.1016/j.jim.2012.07.019. Epub 2012 Aug 2. J Immunol Methods. 2012. PMID: 22884621
-
Myositis-specific and myositis-associated autoantibodies in Indian patients with inflammatory myositis.Rheumatol Int. 2016 Jul;36(7):935-43. doi: 10.1007/s00296-016-3494-3. Epub 2016 May 14. Rheumatol Int. 2016. PMID: 27193471
-
Classification, diagnosis, and management of idiopathic inflammatory myopathies.J Rheumatol. 2013 May;40(5):550-64. doi: 10.3899/jrheum.120682. Epub 2013 Mar 15. J Rheumatol. 2013. PMID: 23504386 Review.
Cited by
-
A Case of Amyloid Myopathy Mimicking Anti-Mi-2 Antibody-Positive Myositis.J Gen Intern Med. 2024 Sep 9. doi: 10.1007/s11606-024-09012-1. Online ahead of print. J Gen Intern Med. 2024. PMID: 39249649 No abstract available.
-
Paraneoplastic dermatomyositis and Stevens-Johnson syndrome related to immunotherapy.Immunotherapy. 2024;16(11):709-714. doi: 10.1080/1750743X.2024.2362107. Epub 2024 Jun 18. Immunotherapy. 2024. PMID: 38888430 Review.
-
Current Biomarker Strategies in Autoimmune Neuromuscular Diseases.Cells. 2023 Oct 15;12(20):2456. doi: 10.3390/cells12202456. Cells. 2023. PMID: 37887300 Free PMC article. Review.
-
Anti-Mi-2 antibody-positive lung cancer-associated polymyositis.Int Cancer Conf J. 2023 Mar 14;12(3):173-176. doi: 10.1007/s13691-023-00601-1. eCollection 2023 Jul. Int Cancer Conf J. 2023. PMID: 37251005 Free PMC article.
-
AC-X: Characteristic Antinuclear Antibody Patterns of Two Anti-Mi-2 Autoantibody-Positive Dermatomyositis Patients-A Case Report.Front Immunol. 2022 Mar 17;13:857030. doi: 10.3389/fimmu.2022.857030. eCollection 2022. Front Immunol. 2022. PMID: 35371082 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
