Hospital Outbreak Caused by a Carbapenem-Resistant Strain of Acinetobacter Baumannii: Patient Prognosis and Risk-Factors for Colonisation and Infection

Clin Microbiol Infect. 2005 Jul;11(7):540-6. doi: 10.1111/j.1469-0691.2005.01184.x.

Abstract

Between October 2001 and August 2002, 30 hospital patients became infected or colonised by a multiresistant (including to carbapenems) epidemic strain of Acinetobacter baumannii (AbMR) in a hospital outbreak. This study analysed the risk-factors associated with acquisition of this epidemic strain and investigated the prognosis of patients infected by AbMR, with the aim of elucidating factors which lead to mortality. A case-control study of the acquisition of AbMR in patients infected or colonised in the hospital outbreak was performed. Independent risk-factors leading to death were studied by logistic regression analysis. Multivariate analysis of the risk-factors for colonisation/infection with AbMR revealed an independent association with the presence of an arterial catheter (OR, 1.13; 95% CI, 1.03-1.25) and administration of imipenem as monotherapy (OR, 11.12; 95% CI, 2.33-53.09). Multivariate analysis of the prognostic features leading to mortality revealed a significant association with hypotension or shock (OR, 24.63; 95% CI, 1.56-387.56) at the time of bacterial isolation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / epidemiology
  • Acinetobacter Infections / microbiology*
  • Acinetobacter Infections / mortality
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / isolation & purification
  • Adult
  • Aged
  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / pharmacology*
  • Case-Control Studies
  • Catheterization, Peripheral
  • Cross Infection / microbiology*
  • Disease Outbreaks*
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Humans
  • Hypotension
  • Imipenem / therapeutic use
  • Logistic Models
  • Male
  • Risk Factors
  • Shock
  • Spain

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Imipenem