Hox clusters as models for vertebrate genome evolution

Trends Genet. 2005 Aug;21(8):421-4. doi: 10.1016/j.tig.2005.06.004.


The surprising variation in the number of Hox clusters and the genomic architecture within vertebrate lineages, especially within the ray-finned fish, reflects a history of duplications and subsequent lineage-specific gene loss. Recent research on the evolution of conserved non-coding sequences (CNS) in Hox clusters promises to reveal interesting results for functional and phenotypic diversification.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Conserved Sequence
  • DNA / genetics
  • Evolution, Molecular
  • Fishes / genetics
  • Gene Duplication
  • Genes, Homeobox*
  • Genome
  • Humans
  • Models, Genetic*
  • Multigene Family*
  • Sequence Homology, Nucleic Acid
  • Vertebrates / genetics


  • DNA