Acute renal failure in CF patients chronically infected by the Liverpool epidemic Pseudomonas aeruginosa strain (LES)

J Cyst Fibros. 2005 Sep;4(3):197-201. doi: 10.1016/j.jcf.2005.05.017.


Although acute renal failure has been described in children with CF in relation to intravenous aminoglycoside use, there are no reports in the adult CF literature. We describe 8 cases of acute renal failure in adult CF patients, all occurring during the use of intravenous aminoglycosides for the treatment of pulmonary exacerbations with an epidemic multi-resistant Pseudomonas aeruginosa strain. Potential contributory factors are discussed. These cases demonstrate another complication of infection by epidemic Pseudomonas strains in CF, and confirm the need for effective segregation policies to prevent this.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Adolescent
  • Adult
  • Aminoglycosides / adverse effects*
  • Aminoglycosides / therapeutic use
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Chronic Disease
  • Cystic Fibrosis / drug therapy*
  • Cystic Fibrosis / microbiology
  • Disease Outbreaks*
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Pseudomonas Infections / drug therapy*
  • Pseudomonas Infections / microbiology
  • Pseudomonas aeruginosa / isolation & purification*
  • Retrospective Studies
  • United Kingdom / epidemiology


  • Aminoglycosides
  • Anti-Bacterial Agents