The HERC proteins: functional and evolutionary insights

Cell Mol Life Sci. 2005 Aug;62(16):1826-38. doi: 10.1007/s00018-005-5119-y.


HERC proteins are defined as containing both HECT and RCC1-like domains in their amino acid sequences. Six HERC genes have turned up in the human genome which encode two different sorts of polypeptides: while the small HERC proteins possess little more than the two aforementioned domains, the large ones are giant proteins with a plethora of potentially important regions. It is now almost 10 years since the discovery of the first family member and information is starting to accumulate pointing to a general role for these proteins as ubiquitin ligases involved in membrane-trafficking events. In this review, the available data on these six members are discussed, together with an account of their evolution.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Evolution, Molecular*
  • Humans
  • Models, Molecular
  • Phylogeny
  • Protein Structure, Tertiary
  • Ubiquitin-Protein Ligases / chemistry
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / physiology*


  • Ubiquitin-Protein Ligases