Elevated serum manganese superoxide dismutase in acute leukemias

Cancer Lett. 1992 Mar 15;62(3):211-5. doi: 10.1016/0304-3835(92)90098-g.

Abstract

We measured the serum levels of manganese-superoxide dismutase (Mn-SOD) in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Serum Mn-SOD level for normal subjects was 94.1 +/- 23.5 ng/ml (mean +/- S.D.), the levels for AML and ALL patients were 159.6 +/- 77.1 ng/ml and 154.4 +/- 77.0 ng/ml, respectively. The serum Mn-SOD levels were unrelated to individual intracellular Mn-SOD levels, but correlated well with serum lactate dehydrogenase values. Regression of the leukemia was accompanied by decrease in the serum level of Mn-SOD. Serum Mn-SOD may thus serve as a measure of the activity of the disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme-Linked Immunosorbent Assay
  • Follow-Up Studies
  • Humans
  • L-Lactate Dehydrogenase / blood
  • Leukemia, Myeloid, Acute / enzymology*
  • Monocytes / enzymology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology*
  • Superoxide Dismutase / blood*

Substances

  • L-Lactate Dehydrogenase
  • Superoxide Dismutase