Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart

Magn Reson Med. 2005 Jul;54(1):196-200. doi: 10.1002/mrm.20516.


The ability of MnCl2 to enhance canine myocardium and to delineate ischemic areas is demonstrated. A dose-response curve was measured using T1 weighted images in 11 dogs. MnCl2 (36, 113, 360, and 3600 micromol) was infused over a period of 3 min. Signal intensity increased linearly with MnCl2 dose. At 113 micromol ( approximately 10 micromol/kg) the steady-state increase in intensity averaged 212 +/- 34%. No significant physiologic effects due to the infused MnCl2 were detected except at the highest dose where there was a cardiac depressive effect. Ischemia was induced by occluding the left anterior descending coronary artery in 5 dogs. At an infused dose of 113 micromol, MnCl2 clearly demarcated the ischemic zone during coronary occlusion. Contrast enhancement in the ischemic zone was less than 30% compared with normal tissue (P < 0.03). In conclusion, the intracellular contrast agent MnCl2 enhances the canine heart and shows promise in detecting ischemia at doses that do not cause adverse cardiac effects.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, P.H.S.
  • Validation Study

MeSH terms

  • Animals
  • Contrast Media*
  • Dogs
  • Dose-Response Relationship, Drug
  • Heart Ventricles / drug effects
  • Heart Ventricles / pathology
  • Image Enhancement / methods*
  • Infusions, Intra-Arterial
  • Magnesium Chloride / administration & dosage*
  • Magnetic Resonance Imaging / methods*
  • Myocardial Ischemia / complications
  • Myocardial Ischemia / pathology*
  • Reference Values
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Ventricular Dysfunction, Left / etiology
  • Ventricular Dysfunction, Left / pathology*


  • Contrast Media
  • Magnesium Chloride