Quantification of L-type fatty acid binding protein in the urine of preterm neonates

Early Hum Dev. 2005 Jul;81(7):643-6. doi: 10.1016/j.earlhumdev.2005.03.012.


We measured urinary excretion of L-type fatty acid binding protein (L-FABP) in preterm neonates on days 1, 5-10, and 25-30 of life. Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults. They did not change significantly during the study period. Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta-D-glucosaminidase activity on day 1, and with those of 8-hydroxy-2'-deoxyguanosine on days 25-30. These results suggest that L-FABP is expressed in the neonatal kidney. Our results may also point to potential effects of proximal tubular damage and oxidative stress on urinary excretion of L-FABP.

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Acetylglucosaminidase / urine
  • Deoxyguanosine / analogs & derivatives
  • Deoxyguanosine / urine
  • Humans
  • Infant, Newborn
  • Infant, Premature / urine*
  • Kidney / metabolism


  • 8-Hydroxy-2'-Deoxyguanosine
  • Acetylglucosaminidase
  • Deoxyguanosine