Timing of prophylactic antibiotic administration in the uninfected laboring gravida: a randomized clinical trial

Am J Obstet Gynecol. 2005 Jun;192(6):1864-8; discussion 1868-71. doi: 10.1016/j.ajog.2004.12.063.


Objective: The purpose of this prospective study was to determine whether the timing of prophylactic antibiotics at cesarean delivery influences maternal/neonatal infectious morbidity.

Study design: In this double-blind placebo-controlled trial, cefazolin was given at skin incision (group A) or at cord clamping (group B). Patients were eligible for the trial if they had labored and required a cesarean delivery.

Results: Over a 30-month period 303 patients with singleton pregnancies entered the trial; 153-group A, 149-group B. Demographics, indication for cesarean delivery (P = .54), and operative time (P = .999), as well as rates of endometritis (RR 0.67, 95% CI 0.42-1.07), wound infection (RR 0.84, 95% CI 0.45-1.55), neonatal sepis (RR 1.28, 95% CI 0.91-1.79), and NICU admissions (RR 1.28, 95% CI 0.91-1.79) were similar between the 2 groups.

Conclusion: There was no difference in maternal infectious morbidity whether antibiotics were given before skin incision or at cord clamping.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage*
  • Antibiotic Prophylaxis*
  • Cesarean Section / methods*
  • Drug Administration Schedule
  • Female
  • Humans
  • Labor, Obstetric*
  • Pregnancy
  • Prospective Studies
  • Puerperal Infection / prevention & control*
  • Surgical Wound Infection / prevention & control
  • Time Factors
  • Treatment Outcome


  • Anti-Bacterial Agents