Short-course chemotherapy for paediatric respiratory tuberculosis: 5-year report

Int J Tuberc Lung Dis. 2005 Jun;9(6):693-6.


This report presents the 5-year follow-up of 137 children with respiratory tuberculosis enrolled in a randomised clinical trial of two different anti-tuberculosis regimens 9HR and 2HRZ3/4RH2. Both regimens had similar cure rates, with low relapse rates and mortality. Of 134 children followed up to 5 years, 86% had normal radiographs, with more sequelae in the 9HR group (15% vs. 1.5%, P < 0.01). One patient relapsed and there was one accidental death. Short-course chemotherapy in children is safe, effective and well tolerated, and leads to excellent long-term results, with a small proportion of children left with radiological sequelae.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Antitubercular Agents / administration & dosage*
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Follow-Up Studies
  • Humans
  • Infant
  • Isoniazid / administration & dosage
  • Pyrazinamide / administration & dosage
  • Rifampin / administration & dosage
  • Statistics, Nonparametric
  • Tuberculosis, Pulmonary / drug therapy*


  • Antitubercular Agents
  • Pyrazinamide
  • Isoniazid
  • Rifampin