Detecting curable disease following hepatectomy for colorectal metastases

ANZ J Surg. 2005 Jul;75(7):524-7. doi: 10.1111/j.1445-2197.2005.03421.x.

Abstract

Introduction: Although resection may be curative for patients with hepatic colorectal metastases, recurrence occurs in the majority. Recurrence is occasionally amenable to repeated resection. The aim of the present study was to evaluate which modalities, at what intervals, detected potentially curable resection.

Methods: The records of patients undergoing hepatectomy for colorectal metastases over 10 years in one centre were retrospectively reviewed to determine when and how recurrence was diagnosed. Specific attention was paid to the detection of potentially curable disease.

Results: Of 41 recurrences, 22 occurred in the first year postoperatively, 21 of which were suitable for palliative treatment only. Ten of 19 recurrences occurring after 1 year underwent potentially curative intervention, 10 were diagnosed by computed tomography (CT). Carcinoembryonic antigen did not diagnose any curable recurrence.

Conclusions: A follow-up protocol is proposed, based on annual CT.

MeSH terms

  • Biomarkers, Tumor
  • Carcinoembryonic Antigen / blood
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / pathology
  • Colorectal Neoplasms / surgery*
  • Hepatectomy / adverse effects*
  • Humans
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery*
  • Neoplasm Recurrence, Local / blood
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Recurrence, Local / etiology
  • Neoplasm Recurrence, Local / therapy*
  • Retrospective Studies
  • Tomography, Spiral Computed

Substances

  • Biomarkers, Tumor
  • Carcinoembryonic Antigen