BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks

Steven Maere; Karel Heymans; Martin Kuiper

doi:10.1093/bioinformatics/bti551

BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks

Bioinformatics. 2005 Aug 15;21(16):3448-9. doi: 10.1093/bioinformatics/bti551. Epub 2005 Jun 21.

Authors

Steven Maere¹, Karel Heymans, Martin Kuiper

Affiliation

¹ Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052, Ghent, Belgium.

PMID: 15972284
DOI: 10.1093/bioinformatics/bti551

Abstract

The Biological Networks Gene Ontology tool (BiNGO) is an open-source Java tool to determine which Gene Ontology (GO) terms are significantly overrepresented in a set of genes. BiNGO can be used either on a list of genes, pasted as text, or interactively on subgraphs of biological networks visualized in Cytoscape. BiNGO maps the predominant functional themes of the tested gene set on the GO hierarchy, and takes advantage of Cytoscape's versatile visualization environment to produce an intuitive and customizable visual representation of the results.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms*
Animals
Computer Graphics
Computer Simulation
Gene Expression Profiling / methods*
Gene Expression Regulation / physiology*
Humans
Models, Biological*
Signal Transduction / physiology*
Software*
User-Computer Interface*