Spontaneous resolution of hemophagocytic syndrome and disseminated intravascular coagulation associated with parvovirus b19 infection in a previously healthy child

Jpn J Infect Dis. 2005 Jun;58(3):149-51.


A 10-year-old male with a brain abscess developed pancytopenia, liver dysfunction, disseminated intravascular coagulation (DIC) and decrease of immunoglobulin A (IgA) level during postoperative antibiotic and anticonvulsant therapy. A bone marrow examination revealed hemophagocytosis. Real-time PCR revealed parvovirus B19 infection. The hemophagocytic syndrome resolved without specific treatment. To our knowledge, this is the first report of a spontaneous resolution of parvovirus B19-associated hemophagocytic syndrome and DIC.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Disseminated Intravascular Coagulation / virology*
  • Histiocytosis, Non-Langerhans-Cell / virology*
  • Humans
  • Male
  • Parvoviridae Infections / complications*
  • Parvovirus B19, Human*
  • Remission, Spontaneous