FcgammaRIIIb Genotypes and Smoking in Periodontal Disease Progression Among Community-Dwelling Older Adults in Japan

J Periodontol. 2005 Feb;76(2):250-5. doi: 10.1902/jop.2005.76.2.250.


Background: FcgammaRIIIb genotypes and smoking are risk factors for periodontal disease. However, the interaction of FcgammaRIIIb- NA1-NA2 polymorphism with smoking remains unclear. The purpose of this study was to determine if FcgammaRIIIb-NA1-NA2 polymorphism and smoking are associated with periodontal disease progression among elderly people.

Methods: Among 70-year-old subjects, 164 with neither diabetes mellitus nor blood sugar > or =140 mg/dl, who had more than 20 teeth and who could participate in both the baseline and the follow-up examinations were included in the study. The NA1 group comprised subjects with FcgammaRIIIb-NA1NA1 genotype (N = 53), while the NA2 group included subjects with FcgammaRIIIb-NA1NA2 or NA2NA2 genotype (N = 111). We examined the progression of periodontitis by measuring attachment loss during 3 years.

Results: The frequency of subjects who showed > or =4 mm additional attachment loss at one or more sites was 55.6% for smokers and 37.2% for non-smokers. The odds ratio (OR) was 2.13 (confidence interval [CI]: 0.92 to 4.76). We found a better association between periodontal progression and smoking in the NA2 group. The OR for smokers was 3.03 (CI:1.12 to 8.33, P = 0.028). Additionally, the mean number of sites with > or =4 mm additional attachment loss per person between smokers and non-smokers in the NA2 group or between smokers and non-smokers in the NA1 group was 2.90 3.42 and 0.74 1.53 or 0.57 0.79 and 0.68 1.03, respectively (P <0.001; analysis of variance [ANOVA]).

Conclusion: Our results may suggest an association between smoking and periodontal disease progression in elderly people with FcgammaRIIIb-NA2 polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Aged
  • Analysis of Variance
  • Antigens, CD / genetics*
  • Chi-Square Distribution
  • Disease Progression
  • Female
  • GPI-Linked Proteins
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Japan
  • Male
  • Odds Ratio
  • Periodontal Diseases / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Receptors, IgG / genetics*
  • Regression Analysis
  • Sex Factors
  • Smoking / genetics*


  • Antigens, CD
  • FCGR3B protein, human
  • GPI-Linked Proteins
  • Receptors, IgG