Allosterism at muscarinic receptors: ligands and mechanisms

Mini Rev Med Chem. 2005 Jun;5(6):523-43. doi: 10.2174/1389557054023251.


The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

Publication types

  • Review

MeSH terms

  • Animals
  • Cholinergic Agents / chemistry
  • Cholinergic Agents / pharmacology*
  • Humans
  • Ligands
  • Receptors, Muscarinic / chemistry*
  • Receptors, Muscarinic / classification
  • Receptors, Muscarinic / drug effects*
  • Structure-Activity Relationship


  • Cholinergic Agents
  • Ligands
  • Receptors, Muscarinic