COPII-coated vesicles: flexible enough for large cargo?

Curr Opin Cell Biol. 2005 Aug;17(4):345-52. doi: 10.1016/


Cargo proteins exiting the endoplasmic reticulum en route to the Golgi are typically carried in 60-70 nm vesicles surrounded by the COPII protein coat. Some secretory cargo assemblies in specialized mammalian cells are too large for transport within such carriers. Recent studies on procollagen-I and chylomicron trafficking have reached conflicting conclusions regarding the role of COPII proteins in ER exit of these large biological assemblies. COPII is no doubt essential for such transport in vivo, but it remains unclear whether COPII envelops the membrane surrounding large cargo or instead plays a more indirect role in transport carrier biogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • COP-Coated Vesicles / metabolism*
  • Endoplasmic Reticulum / metabolism
  • Fibrillar Collagens / metabolism
  • Golgi Apparatus / metabolism
  • Lipoproteins / metabolism


  • Fibrillar Collagens
  • Lipoproteins