Bmi1 in development and tumorigenesis of the central nervous system

J Mol Med (Berl). 2005 Aug;83(8):596-600. doi: 10.1007/s00109-005-0682-0. Epub 2005 Jun 23.


The role of the Polycomb group gene Bmi1 in proliferation control of lymphoid and neuronal progenitors as well as in self-renewal of haematopoietic and neural stem cells has been recently demonstrated. Here we review these recent findings with particular regard to their implications for central nervous system development and tumorigenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Central Nervous System / growth & development*
  • Central Nervous System Neoplasms / etiology*
  • Central Nervous System Neoplasms / genetics
  • Humans
  • Nuclear Proteins / genetics*
  • Polycomb Repressive Complex 1
  • Proto-Oncogene Proteins / genetics*
  • Repressor Proteins / genetics*


  • BMI1 protein, human
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Polycomb Repressive Complex 1