Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis

Angew Chem Int Ed Engl. 2005 Jul 25;44(30):4757-60. doi: 10.1002/anie.200462784.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Coenzyme A Ligases / chemistry
  • Molecular Conformation
  • Polyketide Synthases / chemistry*
  • Polyketide Synthases / genetics*
  • Polyketide Synthases / metabolism
  • Sirolimus / chemistry
  • Sirolimus / metabolism*
  • Stereoisomerism
  • Streptomyces / metabolism

Substances

  • Polyketide Synthases
  • Coenzyme A Ligases
  • Sirolimus