Etiology and pathogenesis of periodontal diseases

Dent Clin North Am. 2005 Jul;49(3):491-516, v. doi: 10.1016/j.cden.2005.03.001.


The two most prevalent and most investigated periodontal diseases are dental plaque-induced gingivitis and chronic periodontitis. The last 10 to 15 years have seen the emergence of several important new findings and concepts regarding the etiopathogenesis of periodontal diseases. These findings include the recognition of dental bacterial plaque as a biofilm, identification and characterization of genetic defects that predispose individuals to periodontitis, host-defense mechanisms implicated in periodontal tissue destruction, and the interaction of risk factors with host defenses and bacterial plaque. This article reviews current aspects of the etiology and pathogenesis of periodontal diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biofilms
  • Chronic Disease
  • Dental Plaque / microbiology
  • Genetic Predisposition to Disease
  • Gingivitis / etiology
  • Humans
  • Immunity, Cellular / immunology
  • Inflammation Mediators / physiology
  • Periodontal Diseases / etiology*
  • Periodontitis / etiology


  • Inflammation Mediators