How Do DCs Interact With Intestinal Antigens?

Trends Immunol. 2005 Jul;26(7):349-52. doi: 10.1016/


Recent evidence demonstrates that dendritic cells (DCs) can insert dendrites between the epithelial cells that form the barrier protecting the body from the gut contents. Although first observed almost a decade ago, this is a controversial area of DC biology and the physiological importance of this phenomenon is only now being clarified. A recent study by Niess and colleagues shows that this behaviour enables efficient sampling of both invasive and non-invasive bacteria and might enhance the ability of an organism to resist infections by a pathogenic strain of Salmonella.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens / administration & dosage
  • Antigens, Bacterial / administration & dosage
  • Dendritic Cells / immunology*
  • Dendritic Cells / microbiology
  • Immune Tolerance
  • Intestines / immunology*
  • Intestines / microbiology
  • Lymph Nodes / immunology
  • Lymph Nodes / microbiology
  • Salmonella / immunology
  • Salmonella / pathogenicity


  • Antigens
  • Antigens, Bacterial