The course of cognitive functioning in first episode psychosis: changes over time and impact on outcome

Schizophr Res. 2005 Oct 1;78(1):35-43. doi: 10.1016/j.schres.2005.05.008.


This three year longitudinal study examined the cognitive performance of 247 individuals who recently presented with a first episode of psychosis. Using a comprehensive battery of cognitive tests, we assessed cognition at baseline, 1 year and 2-year follow-ups. Assessments also included positive and negative symptoms, depression, social outcome and substance use. There were several significant improvements in cognition over the two-year period which were usually matched by improvements in a matched non-psychiatric control group. Regression analyses demonstrated that after controlling for symptoms cognitive impairment accounted for 4-6% of the variance in social functioning. Our results suggest that impaired cognition exists in the very early stages of a psychotic illness and that there is no decline over time. Secondly, our results suggest that, although related, poor social functioning deficits may be independent of cognitive impairment. Finally there are implications for improved methodology in the assessment of both cognitive and social functioning.

MeSH terms

  • Adolescent
  • Adult
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / psychology
  • Comorbidity
  • Depression / diagnosis
  • Depression / psychology
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Neuropsychological Tests / statistics & numerical data*
  • Outcome Assessment, Health Care
  • Prognosis
  • Psychiatric Status Rating Scales
  • Psychometrics
  • Psychotic Disorders / diagnosis*
  • Psychotic Disorders / psychology
  • Substance-Related Disorders / diagnosis
  • Substance-Related Disorders / psychology