The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis

Atherosclerosis. 2006 Feb;184(2):342-7. doi: 10.1016/j.atherosclerosis.2005.05.004. Epub 2005 Jun 23.


Background: CD163 is a monocyte-macrophage lineage specific scavenger receptor that mediates the uptake and clearance of haptoglobin-haemoglobin complexes, and soluble CD163 (sCD163) is also present in plasma. As atherosclerosis involves infiltration by monocyte-derived macrophages, we investigated whether sCD163 may act as a marker of coronary atherosclerosis (CAD).

Methods and results: Clinical features were identified and plasma was collected from 147 consecutive patients presenting for coronary angiography. Patients were classified as having CAD+, or being free of CAD- haemodynamically significant (>50% luminal diameter) coronary stenoses in one or more major coronary arteries (1, 2 or 3 vessel disease), and sCD163 concentration was measured by ELISA. Plasma sCD163 was non-parametrically distributed, being significantly higher in CAD+ patients (median 2.47 mg/L, 25th-75th percentile, 1.79-3.5mg/L) than in CAD- patients (2.09, 1.31-2.72 mg/L) (p=0.021, Mann-Whitney U-test). LogsCD163 increased significantly with increasing CAD extent (p=0.0036) and was significantly greater in patients with 3 vessel disease than in CAD- patients (p<0.001). Whereas logsCD163 correlated with CAD extent (Spearman r=0.22, p=0.008), logCRP did not, and sCD163 was only weakly correlated with CRP (r=0.19, p=0.039). Importantly, multivariate linear regression identified that sCD163 (p=0.0021) was a significant predictor of CAD extent and was independent of conventional risk factors age (p<0.0001), hypercholesterolemia (p=0.0023), hypertension (p=0.068), and current smoking (p=0.066).

Conclusions: The monocyte-specific marker sCD163 is a novel potential plasma marker of coronary atherosclerotic burden.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / blood*
  • Antigens, Differentiation, Myelomonocytic / blood*
  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • Coronary Angiography
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / diagnostic imaging
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Receptors, Cell Surface / blood*
  • Receptors, Scavenger / blood*
  • Severity of Illness Index


  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Biomarkers
  • CD163 antigen
  • Receptors, Cell Surface
  • Receptors, Scavenger
  • C-Reactive Protein