Golgins and GTPases, giving identity and structure to the Golgi apparatus

Biochim Biophys Acta. 2005 Jul 10;1744(3):383-95. doi: 10.1016/j.bbamcr.2005.02.001. Epub 2005 Feb 25.


In this review we will focus on the recent advances in how coiled-coil proteins of the golgin family give identity and structure to the Golgi apparatus in animal cells. A number of recent studies reveal a common theme for the targeting of golgins containing the ARL-binding GRIP domain, and the related ARF-binding GRAB domain. Similarly, other golgins such as the vesicle tethering factor p115 and Bicaudal-D are targeted by the Rab GTPases, Rab1 and Rab6, respectively. Together golgins and their regulatory GTPases form a complex network, commonly known as the Golgi matrix, which organizes Golgi membranes and regulates membrane trafficking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cytoskeleton / metabolism
  • Golgi Apparatus / enzymology
  • Golgi Apparatus / metabolism*
  • Golgi Apparatus / ultrastructure
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Mitosis / physiology
  • rab GTP-Binding Proteins / chemistry
  • rab GTP-Binding Proteins / metabolism*


  • Membrane Proteins
  • rab GTP-Binding Proteins