Abstract
Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Coagulase / metabolism
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Drug Resistance, Multiple, Bacterial*
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Erythromycin / pharmacology
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Gene Expression Regulation, Bacterial*
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Humans
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Ketolides / pharmacology*
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Macrolides / pharmacology*
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Microbial Sensitivity Tests
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Staphylococcus / classification
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Staphylococcus / drug effects*
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Staphylococcus / enzymology
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Coagulase
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Ketolides
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Macrolides
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Erythromycin
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telithromycin