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. 2005 Jul 1;33(Web Server issue):W72-6.
doi: 10.1093/nar/gki396.

SCRATCH: A Protein Structure and Structural Feature Prediction Server

Free PMC article

SCRATCH: A Protein Structure and Structural Feature Prediction Server

J Cheng et al. Nucleic Acids Res. .
Free PMC article


SCRATCH is a server for predicting protein tertiary structure and structural features. The SCRATCH software suite includes predictors for secondary structure, relative solvent accessibility, disordered regions, domains, disulfide bridges, single mutation stability, residue contacts versus average, individual residue contacts and tertiary structure. The user simply provides an amino acid sequence and selects the desired predictions, then submits to the server. Results are emailed to the user. The server is available at


Figure 1
Figure 1
Flow diagram for the SCRATCH server. DISpro, DOMpro, CONpro and DIpro are grouped together because they have the same inputs and their outputs are not used by other predictors; however, they are standalone programs.

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