SCRATCH: a protein structure and structural feature prediction server

Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W72-6. doi: 10.1093/nar/gki396.


SCRATCH is a server for predicting protein tertiary structure and structural features. The SCRATCH software suite includes predictors for secondary structure, relative solvent accessibility, disordered regions, domains, disulfide bridges, single mutation stability, residue contacts versus average, individual residue contacts and tertiary structure. The user simply provides an amino acid sequence and selects the desired predictions, then submits to the server. Results are emailed to the user. The server is available at

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Disulfides / chemistry
  • Internet
  • Mutation
  • Protein Conformation*
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Proteins / chemistry
  • Proteins / genetics
  • Software*
  • Solvents / chemistry
  • User-Computer Interface


  • Disulfides
  • Proteins
  • Solvents