The Prometheus Device for Extracorporeal Support of Combined Liver and Renal Failure

Blood Purif. 2005;23(4):298-302. doi: 10.1159/000086552. Epub 2005 Jun 23.

Abstract

Background/aims: Prometheus is a newly developed extracorporeal liver support system that combines removal of albumin-bound substances (adsorption on resin adsorbers) and water-soluble substances (diffusion during high-flux hemodialysis). Therefore, it is a promising treatment option for patients with hepatorenal syndrome (HRS).

Methods: We studied 10 patients with HRS in a prospective clinical study. All patients underwent 2 consecutive Prometheus treatments. A variety of clinical and biochemical parameters were assessed.

Results: Prometheus treatment was uncomplicated and safe. A statistically significant improvement of serum creatinine and urea concentrations as well as blood pH was observed after Prometheus treatment. Furthermore, liver detoxification was supported by a significant decrease of serum levels of conjugated bilirubin, bile acids and ammonia.

Conclusions: Prometheus is a safe treatment for patients with HRS. Both, albumin-bound and water-soluble substances were effectively removed. Controlled studies will evaluate the effect of this new treatment option on survival in patients with HRS.

MeSH terms

  • Blood Chemical Analysis
  • Extracorporeal Circulation / instrumentation*
  • Female
  • Hepatorenal Syndrome / therapy*
  • Humans
  • Liver Failure, Acute / therapy
  • Male
  • Serum Albumin / isolation & purification

Substances

  • Serum Albumin