No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors

Eisho Yoshikawa; Yutaka Matsuoka; Masatoshi Inagaki; Tomohito Nakano; Tatsuo Akechi; Makoto Kobayakawa; Maiko Fujimori; Naoki Nakaya; Nobuya Akizuki; Shigeru Imoto; Koji Murakami; Yosuke Uchitomi

doi:10.1007/s10549-005-1412-6

No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors

Breast Cancer Res Treat. 2005 Jul;92(1):81-4. doi: 10.1007/s10549-005-1412-6.

Authors

Eisho Yoshikawa¹, Yutaka Matsuoka, Masatoshi Inagaki, Tomohito Nakano, Tatsuo Akechi, Makoto Kobayakawa, Maiko Fujimori, Naoki Nakaya, Nobuya Akizuki, Shigeru Imoto, Koji Murakami, Yosuke Uchitomi

Affiliation

¹ Psycho-Oncology Division, National Cancer Center Research Institute, 6-5-1 Kashiwanoha, Kashiwa 277-8577, Japan.

PMID: 15980995
DOI: 10.1007/s10549-005-1412-6

Abstract

We investigated the adverse effects of adjuvant chemotherapy on the hippocampus in Japanese breast cancer survivors with (n=44) and without (n=31) adjuvant chemotherapy. There were no significant differences in hippocampal volume (magnetic resonance imaging) or additionally in memory function (Wechsler Memory Scale-Revised) between the two groups.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / adverse effects*
Antineoplastic Agents / pharmacology*
Antineoplastic Agents / therapeutic use
Breast Neoplasms / drug therapy*
Breast Neoplasms / surgery
Female
Hippocampus / drug effects*
Humans
Japan
Magnetic Resonance Imaging
Mastectomy
Memory Disorders / chemically induced*
Memory Disorders / diagnosis
Middle Aged
Neuropsychological Tests
Organ Size / drug effects
Survivors

Substances

Antineoplastic Agents