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. 2005 Jul;6(7):1234-41.
doi: 10.1002/cbic.200400421.

High-throughput Evaluation of Antioxidant and Pro-Oxidant Activities of Polyphenols With Thymidine Protection Assays

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High-throughput Evaluation of Antioxidant and Pro-Oxidant Activities of Polyphenols With Thymidine Protection Assays

Stéphane Meunier et al. Chembiochem. .

Abstract

A recently reported high-throughput screening strategy has been applied to the rapid selection of new water-soluble antioxidants that display strong protective activities. Based on a competitive immunoassay, a triple-screening procedure was used to evaluate the ability of different compounds to protect thymidine under different oxidative stresses. The pro-oxidant effect of norbadione A in the presence of iron was observed, while some pulvinic acid derivatives proved strongly protective during gamma radiolysis, UV irradiation, and Fenton-like oxidation.

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