The immunological synapse and Rho GTPases

Curr Top Microbiol Immunol. 2005;291:61-90. doi: 10.1007/3-540-27511-8_5.


Rho GTPases are molecular switches controlling a broad range of cellular processes including lymphocyte activation. Not surprisingly, Rho GTPases are now recognized as pivotal regulators of antigen-specific T cell activation by APCs and immunological synapse formation. This review summarizes recent advances in our understanding of how Rho GTPase-dependent pathways control T lymphocyte motility, polarization and activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Cytoskeleton / immunology
  • Humans
  • Lymphocyte Activation
  • Receptors, Antigen, T-Cell / physiology
  • Signal Transduction
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / physiology
  • rho GTP-Binding Proteins / physiology*


  • Receptors, Antigen, T-Cell
  • rho GTP-Binding Proteins