Naturally arising CD25+CD4+ regulatory T cells in tumor immunity

Curr Top Microbiol Immunol. 2005;293:287-302. doi: 10.1007/3-540-27702-1_13.


Naturally arising regulatory T (TR) cells, represented by CD25+CD4+ TR cells, play an essential role in maintaining immunological self-tolerance. This T cell-mediated dominant control of the immune response not only inhibits the development of autoimmune disease, but also impedes effective immunosurveillance against autologous tumor cells. Attenuation of TR cell-mediated immune suppression can therefore evoke effective tumor immunity in otherwise nonresponsive animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited when devising a novel immunotherapy for cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity
  • CD4-Positive T-Lymphocytes / immunology*
  • Humans
  • Immune Tolerance
  • Immunity
  • Neoplasms / immunology*
  • Receptors, Interleukin-2 / immunology*
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology*


  • Receptors, Interleukin-2