Home-based therapy with ready-to-use therapeutic food is of benefit to malnourished, HIV-infected Malawian children

Acta Paediatr. 2005 Feb;94(2):222-5. doi: 10.1111/j.1651-2227.2005.tb01895.x.


Aim: To determine if home-based nutritional therapy will benefit a significant fraction of malnourished, HIV-infected Malawian children, and to determine if ready-to-use therapeutic food (RUTF) is more effective in home-based nutritional therapy than traditional foods.

Methods: 93 HIV-positive children >1 y old discharged from the nutrition unit in Blantyre, Malawi were systematically allocated to one of three dietary regimens: RUTF, RUTF supplement or blended maize/soy flour. RUTF and maize/soy flour provided 730 kJ x kg(-1) x d(-1), while the RUTF supplement provided a fixed amount of energy, 2100 kJ/d. These children did not receive antiretroviral chemotherapy. Children were followed fortnightly. Children completed the study when they reached 100% weight-for-height, relapsed or died. Outcomes were compared using regression modeling to account for differences in the severity of malnutrition between the dietary groups.

Results: 52/93 (56%) of all children reached 100% weight-for-height. Regression modeling found that the children receiving RUTF gained weight more rapidly and were more likely to reach 100% weight-for-height than the other two dietary groups (p < 0.05).

Conclusion: More than half of malnourished, HIV-infected children not receiving antiretroviral chemotherapy benefit from home-based nutritional rehabilitation. Home-based therapy RUTF is associated with more rapid weight gain and a higher likelihood of reaching 100% weight-for-height.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthropometry
  • Child Nutrition Disorders / diet therapy*
  • Child Nutrition Disorders / virology
  • Child, Preschool
  • Food, Formulated*
  • HIV Infections / complications
  • HIV Infections / diet therapy*
  • Humans
  • Infant
  • Infant Nutrition Disorders / diet therapy*
  • Infant Nutrition Disorders / virology
  • Malawi
  • Prospective Studies
  • Regression Analysis
  • Single-Blind Method