Foxl2 gene and the development of the ovary: a story about goat, mouse, fish and woman

Reprod Nutr Dev. 2005 May-Jun;45(3):377-82. doi: 10.1051/rnd:2005028.


In this review, we describe recent results concerning the genetics of sex determination in mammals. Particularly, we developed the study of the FOXL2 gene and its implication in genetic anomalies in goats (PIS mutation) and humans (BPES). We present the expression of FOXL2 in the ovaries of different species.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Disorders of Sex Development*
  • Female
  • Fishes
  • Forkhead Box Protein L2
  • Forkhead Transcription Factors
  • Gene Expression Regulation, Developmental*
  • Goats
  • Humans
  • Male
  • Mice
  • Ovary / embryology*
  • Ovary / metabolism
  • Sex Determination Processes*
  • Species Specificity
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Transcription, Genetic


  • DNA-Binding Proteins
  • FOXL2 protein, human
  • Forkhead Box Protein L2
  • Forkhead Transcription Factors
  • Foxl2 protein, mouse
  • Transcription Factors