Differences in colorectal carcinoma stage and survival by race and ethnicity

Cancer. 2005 Aug 1;104(3):629-39. doi: 10.1002/cncr.21204.

Abstract

Background: In the United States, blacks with colorectal carcinoma (CRC) presented with more advanced-stage disease and had higher mortality rates compared with non-Hispanic whites. Data regarding other races/ethnicities were limited, especially for Asian/Pacific Islander and Hispanic white subgroups.

Methods: Using data from 11 population-based cancer registries that participate in the Surveillance, Epidemiology and End Results program, the authors evaluated the relation among 18 different races/ethnicities and disease stage and mortality rates among 154,103 subjects diagnosed with CRC from 1988 to 2000.

Results: Compared with non-Hispanic whites, blacks, American Indians, Chinese, Filipinos, Koreans, Hawaiians, Mexicans, South/Central Americans, and Puerto Ricans were 10-60% more likely to be diagnosed with Stage III or IV CRC. Alternatively, Japanese had a 20% lower risk of advanced-stage CRC. With respect to mortality rates, blacks, American Indians, Hawaiians, and Mexicans had a 20-30% greater risk of mortality, whereas Chinese, Japanese, and Indians/Pakistanis had a 10-40 % lower risk.

Conclusions: The authors observed numerous racial/ethnic disparities in the risks of advanced-stage cancer and mortality among patients with CRC, and there was considerable variation in these risks across Asian/Pacific Islander and Hispanic white subgroups. Although the etiology of these disparities was multifactorial, developing screening and treatment programs that target racial/ethnic populations with elevated risks of poor CRC outcomes may be an important means of reducing these disparities.

MeSH terms

  • African Americans / statistics & numerical data*
  • Aged
  • Asian Americans / statistics & numerical data*
  • Colorectal Neoplasms / ethnology*
  • Colorectal Neoplasms / mortality*
  • Colorectal Neoplasms / therapy
  • European Continental Ancestry Group / statistics & numerical data*
  • Female
  • Hispanic Americans / statistics & numerical data*
  • Humans
  • Indians, North American / statistics & numerical data*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Registries
  • SEER Program
  • Survival Rate
  • United States / epidemiology