Diagnosis and treatment of primary glomerular diseases. Membranous nephropathy, focal segmental glomerulosclerosis and IgA nephropathy

Minerva Urol Nefrol. 2005 Sep;57(3):211-36.


Membranous nephropathy, focal segmental glomerulosclerosis (FSGS) and IgA nephropathy are the most frequent and important primary glomerulopathies. Idiopathic membranous nephropathy and primary FSGS usually present with a nephrotic syndrome with or without renal insufficiency, whereas IgA nephropathy is more often characterized by (symptomless) hematuria and proteinuria. Although the outcome of these glomerulopathies is quite variable, many patients will progress to end-stage renal disease. In this review we discuss several aspects of the primary glomerulopathies with emphasis on the potential benefit of specific immunosuppressive regimens.

Publication types

  • Review

MeSH terms

  • Animals
  • Evidence-Based Medicine
  • Glomerulonephritis, IGA* / diagnosis
  • Glomerulonephritis, IGA* / drug therapy
  • Glomerulonephritis, Membranous* / diagnosis
  • Glomerulonephritis, Membranous* / drug therapy
  • Glomerulosclerosis, Focal Segmental* / diagnosis
  • Glomerulosclerosis, Focal Segmental* / drug therapy
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Diseases / diagnosis
  • Kidney Diseases / therapy
  • Nephrotic Syndrome* / diagnosis
  • Nephrotic Syndrome* / drug therapy
  • Treatment Outcome


  • Immunosuppressive Agents