Alicyclic beta-amino acids in Medicinal Chemistry

A Kuhl; M G Hahn; M Dumić; J Mittendorf

doi:10.1007/s00726-005-0212-y

Alicyclic beta-amino acids in Medicinal Chemistry

Amino Acids. 2005 Aug;29(2):89-100. doi: 10.1007/s00726-005-0212-y. Epub 2005 Jun 30.

Authors

A Kuhl¹, M G Hahn, M Dumić, J Mittendorf

Affiliation

¹ Medicinal Chemistry, Business Group Pharma, Bayer Health Care AG, Wuppertal, Germany.

PMID: 15986181
DOI: 10.1007/s00726-005-0212-y

Abstract

The structural element of alicyclic beta-amino acids shows some remarkable biological effects: For some 5- and 6-membered beta-amino acids a unique anti fungal activity has been observed, 7-membered beta-amino acid derivatives have been investigated for neurological disorders. The application of 5-, 6- and 7-membered alicyclic beta-amino acids in Medicinal Chemistry will be reported. [structure: see text]

Publication types

Review

MeSH terms

Amino Acids, Cyclic / chemistry*
Antifungal Agents / chemistry
Central Nervous System Agents / chemistry
Cycloleucine / analogs & derivatives
Cycloleucine / chemical synthesis
Dopamine Plasma Membrane Transport Proteins / metabolism
Stereoisomerism
Structure-Activity Relationship

Substances

Amino Acids, Cyclic
Antifungal Agents
Central Nervous System Agents
Dopamine Plasma Membrane Transport Proteins
Cycloleucine
cispentacin