A new FronTIR in targeted protein degradation and plant development

Cell. 2005 Jul 1;121(7):970-2. doi: 10.1016/j.cell.2005.06.020.

Abstract

Three papers, two in a recent issue of Nature and one in the July issue of Developmental Cell, identify a family of F box proteins as the long-sought receptors for the plant growth hormone auxin. The new studies reveal that auxin, a small molecule, regulates F box proteins, which are involved in ubiquitin-mediated protein degradation. This finding has profound implications for understanding plant physiology and development and for defining new modes of regulation of SCF ubiquitin ligase complexes.

Publication types

  • Review

MeSH terms

  • Arabidopsis Proteins
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • F-Box Proteins / metabolism*
  • Gene Expression Regulation, Plant / physiology
  • Indoleacetic Acids / metabolism*
  • Plant Proteins
  • Plants / embryology*
  • Plants / genetics
  • Plants / metabolism*
  • Receptors, Cell Surface / metabolism*
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • SKP Cullin F-Box Protein Ligases / genetics
  • SKP Cullin F-Box Protein Ligases / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Transcriptional Activation / physiology
  • Ubiquitin / metabolism

Substances

  • ARF1 protein, Arabidopsis
  • Arabidopsis Proteins
  • DNA-Binding Proteins
  • F-Box Proteins
  • Indoleacetic Acids
  • Plant Proteins
  • Receptors, Cell Surface
  • Repressor Proteins
  • TIR1 protein, Arabidopsis
  • Transcription Factors
  • Ubiquitin
  • SKP Cullin F-Box Protein Ligases